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Applied BioSciences $APPB: Innovative CBD System Balancing $ $GBLX $PFE $ $ $ $ $ $CGRW

Posted by AGORACOM at 2:31 PM on Monday, January 27th, 2020

SPONSOR: Applied BioSciences is a vertically integrated company focused on the development and commercialization of novel, science-driven, synthetic cannabinoid therapeutics / biopharmaceuticals; targeting the endocannabinoid system to treat a wide-range of diseases across multiple therapeutic areas. Click Here for More Info
An endocannabinoid deficiency can result in a host of patient afflictions, but this innovative CBD balancing strategy can help patients

All cannabidiol (CBD) is not created equal in clinical practice in terms of implementation. The most frustrating thing for clinicians and also for patients is when an intended protocol doesn’t work. As I discuss later under the “With treatment, start low” section of this article, there are ways to use CBD most effectively.

You probably weren’t taught this in medical school, but CBD works on the endocannabinoid system (ECS). The ECS contains CB1 and CB2 receptors, in addition to other receptors that are activated by the naturally occurring endocannabinoids made in our bodies, called anandamide and 2-AG. We all have CB1 or CB2 receptors within our body — if you have a cat or dog, they have these receptors too. All mammals do. How could it be that we did not even know of the predominance of the ECS until 1992?

What the endocannabinoid system can do

Patients coming in worn out can be a sign of endocannabinoid deficiency and the inability to support their pathways optimally, much like adrenal fatigue. Phytocannabinoids like CBD obtained from hemp products can act on the same receptors as endocannabinoids made in the body. CBD receptors, much like opioid receptors, control pain, but via a different mechanism.

Patients arrive at our clinical practices fatigued, anxious, in pain, inflamed, and lots reach a point of adrenal burnout, adrenal fatigue. Indeed, that is often the case because they are suffering from an endocannabinoid deficiency. We see people who have low adrenal function at noon, and in the evening, they are tired, dragging, eat lunch, get a little spike, and then they start free falling again. They’re flat-lining. How is it that we wake up each morning anticipating with trepidation and run with go, go, go pace and finish the day glad to have survived another day? Life is meant for more than that; it is time to shift our goals from merely surviving to thriving mode!

Researchers observed approximately six years ago that people were more anxious and depressed in the middle of the summer than ever before, a new phenomenon. This goes against what we previously believed, that depression spiked mostly in the holiday season and Thanksgiving and after the winter solstice. But now we’re seeing people are worn out even in summer. Indeed, the endocannabinoid system plays a role here.

Anandamide is one of our endocannabinoids. When it becomes lower, patients are more anxious. There is less healing of the brain, less neurogenesis, and the hypothalamic-pituitary axis is triggered, causing a whole cascade of events to occur. What we now know is that the endocannabinoid system naturally, or with the use of CBD, alters our microbiome in our gut, beneficially affecting the gut-brain axis. The GI tract is the site of many receptors. We make about 70% of our serotonin, the happy-brain chemical, in the GI tract. About 70-80% of our immune system is in our GI tract, so is it any surprise that we have CB1, CB2 regulatory pathways in our GI tract that work via the endocannabinoid system to control inflammation? These same pathways can be regulated using an innovative CBD strategy.

Migraines and the endocannabinoid system

With endocannabinoid deficiency symptoms patients can get migraines. We thought migraines were just triggered by tyramine-rich foods, such as cheese, fermented foods, and salami and other such foods; along with other triggers as well.

However, the endocannabinoid pathway is designed to control pain and inflammation and also regulate the immune system to a large degree. I have found in my clinical practice that innovative CBD strategies can be useful in supporting the health of migraine sufferers.

Treat the brain, treat the pain

The body is designed with innate intelligence to sustain optimal performance. People ask, “Well, how is CBD metabolized?” It’s primarily metabolized through the liver, and as a result, it goes through the cytochrome 450 and other pathways.
Wellness is ultimately about homeostasis. We all know the term entropy, the tendency for the universe to move toward chaos. But our body exerts a phenomenal amount of energy to maintain order and wellness. However, if the endocannabinoid system becomes deficient, this will adversely affect wellness. This endocannabinoid deficiency, in turn, affects the microbiome, contributing to a less healthy endocannabinoidome.

CBD can conserve anandamide that is made by the body, and CBD can support anandamide conservation in an attempt to bring the body back into homeostasis. The endocannabinoid system supports brain health. By treating the brain, it addresses the pain, because if we didn’t have a brain, we wouldn’t feel the pain from a perception perspective.

Anxiety also is a biochemical process. It’s real. A lot of people say, “It’s all in my head.” No, stress is real because it’s a physiological effect. There is biochemistry involved in anxiety. We want to use innovative CBD strategies to support calming pathways and bring peace and harmony into the brain.

Endocannabinoid deficiency issues

If a patient has brain inflammation, neuroplasticity is not going to be as healthy or robust. And the fact is, on a typical day, we lose about 86,400 brain cells. CBD is an anti-inflammatory application. And from a neuropathic perspective, activation of cannabinoid receptors is essential. I’ve looked at research involving the endocannabinoid system relative to cancer medications and so forth. Not being an oncologist, I am not suggesting this is a treatment for cancer, but there are pain, stress and immune challenges that often need to be associated with this disease state, so visiting with one’s provider in this arena is vital.

We can start manifesting symptoms of migraines, fatigue, irritable bowel, whatever it might be, as a result of being subpar, insufficient or deficient of endocannabinoids. An endocannabinoid deficiency manifests itself as simply that the body has gotten worn down, much like low adrenal function, often called adrenal fatigue. So we need to support that pathway to bring it back on track like we would any other functional biochemistry, which our body is designed to do. And since we’re designed to make endocannabinoids, we need to bring those levels back up to par.

With treatment, start low

The goal is to start low and go slow, as a little bit can go a long way for many patients. More is not always better, as each person responds differently based on genetics, biochemistry and individual need.

Just like if you’re performing an adjustment, a little bit of a movement might get the job done. Work with gentle modulation of the endocannabinoid system. You’re working within the innate ability of the body.

Fifteen to 25 milligrams per day is what I start my patients on. In a week or two, if I need to move them up to 25 mg two to three times a day, I will. Once again, if a little bit gets the job done, why more? It is of paramount importance to respect the innate delicate balance physiology of the body. Some patients will need much higher doses because of their endocannabinoid insufficiency or potential genetic polymorphisms. You’re going to encounter genetic polymorphisms, or what I termed mutations of the CBD receptors and the CBD pathway.

I never go to high-milligram doses, especially on patients taking pharmaceutical drugs, without working with their pharmacists, because CBD can affect similar liver detoxification, as well as other biochemical pathways of how drugs are metabolized, much like grapefruit juice, can impact many of the same medications. We want to also support those drug-metabolizing pathways with diet and lifestyle.

CBD, when dosed properly, can positively supplement a health-promoting diet and lifestyle. It’s not a substitute for these things. So, we want to ensure we’re taking steps to support the body at a foundational level. Additionally, we always want to ensure the THC levels in the CBD you are using are less than 0.3%, or that the CBD contains no THC, when targeting hemp-derived CBD.

We all get broken or get older

Endocannabinoid deficiency is associated with low cortisol, stress and adrenal fatigue. We’re all getting older. Our mitochondria are wearing down. Our nitric oxide levels aren’t as robust as they used to be, and we need support at a fundamental level. In regards to the 65 potential molecular targets that are currently known for CBD, there is a lot of untapped potential here relative to stress and aging. Innovative CBD use is a new area; it can be a scary area, but remember, our bodies have been producing endocannabinoids for millennia. All we’re doing is supporting a natural pathway.


Applied BioSciences $APPB: How CBD and The Endocannabinoid System Work Together $ $GBLX $PFE $ $ $ $ $ $CGRW

Posted by AGORACOM at 10:43 AM on Tuesday, January 21st, 2020

SPONSOR: Applied BioSciences is a vertically integrated company focused on the development and commercialization of novel, science-driven, synthetic cannabinoid therapeutics / biopharmaceuticals; targeting the endocannabinoid system to treat a wide-range of diseases across multiple therapeutic areas. Click Here for More Info

Before we can take a look at how CBD and the Endocannabinoid System (ECS) work together, we must first understand the ECS.

The human body has an endocannabinoid system, just like it has an endocrine system and a number of other systems that work together to function. The ECS is what makes it possible for CBD, THC, and other cannabinoids in the marijuana and hemp plants – there are hundreds – to work on the body.

In 1988, researchers found the first cannabinoid receptor in the brain of a rat. They found that the receptors interacted exclusively with receptors found in the cannabis compound, THC. That’s the cannabinoid everyone’s most familiar with because it is the compound responsible for the stoned feeling associated with marijuana consumption.

The researchers discovered that the receptors were concentrated in areas of the brain that plays a role in a number of physiological and mental processes, including emotion, motor coordination, high cognition, and memory.

In 1993, another cannabinoid receptor was discovered. It was found distributed throughout the immune system and peripheral body tissues. It displayed the same reaction to THC as the first receptor.

In 1995, the two receptors, that had been named CB1 and CB2, were found not only in rats, but in humans, and thousands of other species.

As technology advanced, researchers further explored the relationship between cannabinoid receptors in the body, known as endocannabinoids, and the cannabinoid receptors in cannabis compounds such as CBD oil and THC – known as phytocannabinoids.

What is the Purpose of Endocannabinoids?

The endocannabinoid system was discovered in the late 1990s, and since then, researchers have learned a great deal about the relationship between phytocannabinoids and endocannabinoids.

Because we know endocannabinoids are present throughout the body in numerous functions, researchers believe they may help maintain these functions.

Imagine for a moment the body is a machine, where each system works together to keep the machine moving and working. The immune system, for instance, would be the filtration system. The brain would be the motherboard, and the endocannabinoids help to maintain the systems.

CB1 receptors are concentrated in the brain and central nervous system. Your central nervous system is responsible for maintaining all the core functions such as pain perception, stress response, motor activity, and memory.

CB receptors are located in many of the peripheral organs in the body, suggesting they are core components of the cardiovascular system, the immune system, and the muscular system.

Why Phytocannabinoids Matter

Machines, whether due to natural aging, poor maintenance, or damage, may malfunction. And like those machines, our body’s systems and parts can break down and malfunction, causing issues within the entire body and any number of health conditions.

Endocannabinoids help maintains your body’s health, but if the level of endocannabinoids in the body declines, in theory, they’d only be able to maintain the body’s current state of health. As such, there likely wouldn’t be enough to stop it from declining any further. Over time, the health level decreases gradually, and in the process, creates bigger health problems.

That’s where phytocannabinoids, such as CBD come into play.

How CBD Works in the Body

Research has taught us that when CBD bonds with either the CB1 or CB2 receptors in the body, it either alters or improves that receptor’s capabilities, which improves that receptor’s functionality.

If the body is suffering a cannabinoid deficiency, adding them to your body, for example, by using CBD gummies for stress, helps to equalize the deficiency. Right now, studies point to the theory that cannabinoids are a finite resource. The deficiency of cannabinoids may cause a number of health issues, including irritability and headaches.

Essentially, using CBD enables us to boost our ECS. Because it bonds with our CB1 and CBD2 receptors, CBD helps the body maintain vital health functions and helps restore balance, also known as homeostasis, within the body. This is the reason it has so many health benefits.

CBD Benefits

When you really think about it, the majority of health problems can be traced back to an imbalance somewhere in the body.

In a healthy body, all is as it should be, and the body is balanced. In an unhealthy body, however, there is either too much or too little of something (or multiple somethings). This creates a disruption in homeostasis and presents a variety of symptoms, which vary depending on the nature of the imbalance.

Think about the various health conditions that are a result of imbalance, and how CBD can help improve these conditions by restoring balance:

  • Inflammation: This is often characterized by a part of your body swelling, and sometimes becoming hot. It can be incredibly painful, and range from mild, to severe enough to incapacitate someone. Inflammation in the body is linked to autoimmune disorders, arthritis, and bacterial infections. CBD can be helpful to treat inflammation because it suppresses the inflammatory pathways and responses, stimulates regulatory cell production, and manages our pain perception.
  • Seizures: Seizures are the result of erratic electrical impulses in the brain, which causes violent shaking in the body. In patients suffering from two severe forms of epilepsy known as Lennox Gaustat Syndrome and Dravet Syndrome, CBD reduces the number of seizures because it slows down the excitatory nerve activity and subdues the brain’s reaction to the intense signals that cause the overload.
  • Anxiety and stress: Most people experience stress and anxiety as a response to situations that are perceived as unwanted, dangerous, or risky. Hormonal imbalance or excessive messages in the brain boosts cortisol levels and causes you to feel stress. CBD combats this by regulating how your brain responds to stress signals and maintaining normal cortisol levels.

These, of course, are only a few examples of the studies supporting CBD as an effective treatment.

There are hundreds of other studies supporting its use to treat a wide number of other conditions, such as addiction, acne, depression, schizophrenia and more. It’s all because of our ECS, and the fact that our bodies contain parts linked directly to the cannabis plant is pretty amazing.


Terpenoids And Cannabinoids – What’s The Difference? SPONSOR: Applied BioSciences $APPB $ $GBLX $PFE $ $ $ $ $ $CGRW

Posted by AGORACOM at 12:00 PM on Monday, January 6th, 2020

SPONSOR: Applied BioSciences is a vertically integrated company focused on the development and commercialization of novel, science-driven, synthetic cannabinoid therapeutics / biopharmaceuticals that target the endocannabinoid system to treat a wide-range of diseases across multiple therapeutic areas Click Here for More Info

If you have been studying cannabis products in depth to find out that one full-spectrum CBD oil that would suit all your needs then you’d have come across the word terpenes. But what are these terpenes, or as others refer them, terpenoids?

Of course, if you are looking to buy CBD, you would be aware of what cannabinoids are. these are compounds found in the cannabis plants, hemp and marijuana. So now you have two terms cannabinoids and terpenoids – but what’s the difference between the two? let’s take a look at this below:


Cannabinoids like cannabidiol and tetrahydrocannabinol have therapeutic properties. They interact with the natural endocannabinoid system in your body. What they basically do is that they control the functionality of cells – this means they manage cell signaling.

Cannabinoids regulate the receiving, processing, and sending of messages between cells. A cannabinoid like CBD can interact with cannabinoid receptors in the ECS and regulate your mood, anxiety, inflammatory response, and much more.

While THC and CBD are the most popular cannabinoids that have studies supporting their effects, there are hundreds of other cannabinoids too. These include CBG and CBN among others. All cannabinoids come with distinct features.


Terpenes or terpenoids are aromatic molecules not only found in cannabis but in several other plants as well. These as well have therapeutic properties. They are found in fruits as well. Terpenes in the lavender flower are responsible for its unique aroma and soothing properties.

Terpenes also found in citrus fruits and berries too. One terpene that exists in both cannabis as well as a fruit, mango, is myrcene. The aroma of weed that many people appreciate comes from this very terpene. Inside plants, terpenes play a very important role. They protect against the attack of pests, bacteria and other external agents. The amount and type of terpenes in cannabis plants varies from one strain to another.

The Entourage Effect

Experts recommend you to go for a full-spectrum CBD formula because it contains cannabinoids as well as terpenes. Cannabinoids and terpenoids work together to provide better benefits. They have an entourage effect together which enables you to get better result sooner. This is because like cannabinoids, terpenes also have health profiting qualities.

For instance, some terpenes have an anti-inflammatory nature while others are great for stress relief. As you may already be aware, CBD also provides these benefits. Of course, when in combination with other compounds that have similar properties benefits that you drive are more.


Cannabinoids and terpenes are compounds found in the cannabis plant. Both have therapeutic properties but are different. Terpenes are aromatic molecules responsible for the flavor of a plant and fragrance. Cannabinoids interact with the ECS of the body. Together they work even better which is why full-spectrum CBD is revered more than CBD isolate.