Agoracom Blog Home

Posts Tagged ‘#MedicinalCannabis’

Applied BioSciences $APPB: Innovative CBD System Balancing $APH.ca $GBLX $PFE $ACG.ca $ACB.ca $WEED.ca $HIP.ca $WMD.ca $CGRW

Posted by AGORACOM-Eric at 2:31 PM on Monday, January 27th, 2020

SPONSOR: Applied BioSciences is a vertically integrated company focused on the development and commercialization of novel, science-driven, synthetic cannabinoid therapeutics / biopharmaceuticals; targeting the endocannabinoid system to treat a wide-range of diseases across multiple therapeutic areas. Click Here for More Info

https://cdn.chiroeco.com/wp-content/uploads/2020/01/i1-20-digital4-1024x576.jpg
An endocannabinoid deficiency can result in a host of patient afflictions, but this innovative CBD balancing strategy can help patients

All cannabidiol (CBD) is not created equal in clinical practice in terms of implementation. The most frustrating thing for clinicians and also for patients is when an intended protocol doesn’t work. As I discuss later under the “With treatment, start low” section of this article, there are ways to use CBD most effectively.

You probably weren’t taught this in medical school, but CBD works on the endocannabinoid system (ECS). The ECS contains CB1 and CB2 receptors, in addition to other receptors that are activated by the naturally occurring endocannabinoids made in our bodies, called anandamide and 2-AG. We all have CB1 or CB2 receptors within our body — if you have a cat or dog, they have these receptors too. All mammals do. How could it be that we did not even know of the predominance of the ECS until 1992?

What the endocannabinoid system can do

Patients coming in worn out can be a sign of endocannabinoid deficiency and the inability to support their pathways optimally, much like adrenal fatigue. Phytocannabinoids like CBD obtained from hemp products can act on the same receptors as endocannabinoids made in the body. CBD receptors, much like opioid receptors, control pain, but via a different mechanism.

Patients arrive at our clinical practices fatigued, anxious, in pain, inflamed, and lots reach a point of adrenal burnout, adrenal fatigue. Indeed, that is often the case because they are suffering from an endocannabinoid deficiency. We see people who have low adrenal function at noon, and in the evening, they are tired, dragging, eat lunch, get a little spike, and then they start free falling again. They’re flat-lining. How is it that we wake up each morning anticipating with trepidation and run with go, go, go pace and finish the day glad to have survived another day? Life is meant for more than that; it is time to shift our goals from merely surviving to thriving mode!

Researchers observed approximately six years ago that people were more anxious and depressed in the middle of the summer than ever before, a new phenomenon. This goes against what we previously believed, that depression spiked mostly in the holiday season and Thanksgiving and after the winter solstice. But now we’re seeing people are worn out even in summer. Indeed, the endocannabinoid system plays a role here.

Anandamide is one of our endocannabinoids. When it becomes lower, patients are more anxious. There is less healing of the brain, less neurogenesis, and the hypothalamic-pituitary axis is triggered, causing a whole cascade of events to occur. What we now know is that the endocannabinoid system naturally, or with the use of CBD, alters our microbiome in our gut, beneficially affecting the gut-brain axis. The GI tract is the site of many receptors. We make about 70% of our serotonin, the happy-brain chemical, in the GI tract. About 70-80% of our immune system is in our GI tract, so is it any surprise that we have CB1, CB2 regulatory pathways in our GI tract that work via the endocannabinoid system to control inflammation? These same pathways can be regulated using an innovative CBD strategy.

Migraines and the endocannabinoid system

With endocannabinoid deficiency symptoms patients can get migraines. We thought migraines were just triggered by tyramine-rich foods, such as cheese, fermented foods, and salami and other such foods; along with other triggers as well.

However, the endocannabinoid pathway is designed to control pain and inflammation and also regulate the immune system to a large degree. I have found in my clinical practice that innovative CBD strategies can be useful in supporting the health of migraine sufferers.

Treat the brain, treat the pain

The body is designed with innate intelligence to sustain optimal performance. People ask, “Well, how is CBD metabolized?” It’s primarily metabolized through the liver, and as a result, it goes through the cytochrome 450 and other pathways.
Wellness is ultimately about homeostasis. We all know the term entropy, the tendency for the universe to move toward chaos. But our body exerts a phenomenal amount of energy to maintain order and wellness. However, if the endocannabinoid system becomes deficient, this will adversely affect wellness. This endocannabinoid deficiency, in turn, affects the microbiome, contributing to a less healthy endocannabinoidome.

CBD can conserve anandamide that is made by the body, and CBD can support anandamide conservation in an attempt to bring the body back into homeostasis. The endocannabinoid system supports brain health. By treating the brain, it addresses the pain, because if we didn’t have a brain, we wouldn’t feel the pain from a perception perspective.

Anxiety also is a biochemical process. It’s real. A lot of people say, “It’s all in my head.” No, stress is real because it’s a physiological effect. There is biochemistry involved in anxiety. We want to use innovative CBD strategies to support calming pathways and bring peace and harmony into the brain.

Endocannabinoid deficiency issues

If a patient has brain inflammation, neuroplasticity is not going to be as healthy or robust. And the fact is, on a typical day, we lose about 86,400 brain cells. CBD is an anti-inflammatory application. And from a neuropathic perspective, activation of cannabinoid receptors is essential. I’ve looked at research involving the endocannabinoid system relative to cancer medications and so forth. Not being an oncologist, I am not suggesting this is a treatment for cancer, but there are pain, stress and immune challenges that often need to be associated with this disease state, so visiting with one’s provider in this arena is vital.

We can start manifesting symptoms of migraines, fatigue, irritable bowel, whatever it might be, as a result of being subpar, insufficient or deficient of endocannabinoids. An endocannabinoid deficiency manifests itself as simply that the body has gotten worn down, much like low adrenal function, often called adrenal fatigue. So we need to support that pathway to bring it back on track like we would any other functional biochemistry, which our body is designed to do. And since we’re designed to make endocannabinoids, we need to bring those levels back up to par.

With treatment, start low

The goal is to start low and go slow, as a little bit can go a long way for many patients. More is not always better, as each person responds differently based on genetics, biochemistry and individual need.

Just like if you’re performing an adjustment, a little bit of a movement might get the job done. Work with gentle modulation of the endocannabinoid system. You’re working within the innate ability of the body.

Fifteen to 25 milligrams per day is what I start my patients on. In a week or two, if I need to move them up to 25 mg two to three times a day, I will. Once again, if a little bit gets the job done, why more? It is of paramount importance to respect the innate delicate balance physiology of the body. Some patients will need much higher doses because of their endocannabinoid insufficiency or potential genetic polymorphisms. You’re going to encounter genetic polymorphisms, or what I termed mutations of the CBD receptors and the CBD pathway.

I never go to high-milligram doses, especially on patients taking pharmaceutical drugs, without working with their pharmacists, because CBD can affect similar liver detoxification, as well as other biochemical pathways of how drugs are metabolized, much like grapefruit juice, can impact many of the same medications. We want to also support those drug-metabolizing pathways with diet and lifestyle.

CBD, when dosed properly, can positively supplement a health-promoting diet and lifestyle. It’s not a substitute for these things. So, we want to ensure we’re taking steps to support the body at a foundational level. Additionally, we always want to ensure the THC levels in the CBD you are using are less than 0.3%, or that the CBD contains no THC, when targeting hemp-derived CBD.

We all get broken or get older

Endocannabinoid deficiency is associated with low cortisol, stress and adrenal fatigue. We’re all getting older. Our mitochondria are wearing down. Our nitric oxide levels aren’t as robust as they used to be, and we need support at a fundamental level. In regards to the 65 potential molecular targets that are currently known for CBD, there is a lot of untapped potential here relative to stress and aging. Innovative CBD use is a new area; it can be a scary area, but remember, our bodies have been producing endocannabinoids for millennia. All we’re doing is supporting a natural pathway.

source: https://www.chiroeco.com/innovative-cbd/

Applied BioSciences $APPB: How CBD and The Endocannabinoid System Work Together $APH.ca $GBLX $PFE $ACG.ca $ACB.ca $WEED.ca $HIP.ca $WMD.ca $CGRW

Posted by AGORACOM-Eric at 10:43 AM on Tuesday, January 21st, 2020

SPONSOR: Applied BioSciences is a vertically integrated company focused on the development and commercialization of novel, science-driven, synthetic cannabinoid therapeutics / biopharmaceuticals; targeting the endocannabinoid system to treat a wide-range of diseases across multiple therapeutic areas. Click Here for More Info

Before we can take a look at how CBD and the Endocannabinoid System (ECS) work together, we must first understand the ECS.

The human body has an endocannabinoid system, just like it has an endocrine system and a number of other systems that work together to function. The ECS is what makes it possible for CBD, THC, and other cannabinoids in the marijuana and hemp plants – there are hundreds – to work on the body.

In 1988, researchers found the first cannabinoid receptor in the brain of a rat. They found that the receptors interacted exclusively with receptors found in the cannabis compound, THC. That’s the cannabinoid everyone’s most familiar with because it is the compound responsible for the stoned feeling associated with marijuana consumption.

The researchers discovered that the receptors were concentrated in areas of the brain that plays a role in a number of physiological and mental processes, including emotion, motor coordination, high cognition, and memory.

In 1993, another cannabinoid receptor was discovered. It was found distributed throughout the immune system and peripheral body tissues. It displayed the same reaction to THC as the first receptor.

In 1995, the two receptors, that had been named CB1 and CB2, were found not only in rats, but in humans, and thousands of other species.

As technology advanced, researchers further explored the relationship between cannabinoid receptors in the body, known as endocannabinoids, and the cannabinoid receptors in cannabis compounds such as CBD oil and THC – known as phytocannabinoids.

What is the Purpose of Endocannabinoids?

The endocannabinoid system was discovered in the late 1990s, and since then, researchers have learned a great deal about the relationship between phytocannabinoids and endocannabinoids.

Because we know endocannabinoids are present throughout the body in numerous functions, researchers believe they may help maintain these functions.

Imagine for a moment the body is a machine, where each system works together to keep the machine moving and working. The immune system, for instance, would be the filtration system. The brain would be the motherboard, and the endocannabinoids help to maintain the systems.

CB1 receptors are concentrated in the brain and central nervous system. Your central nervous system is responsible for maintaining all the core functions such as pain perception, stress response, motor activity, and memory.

CB receptors are located in many of the peripheral organs in the body, suggesting they are core components of the cardiovascular system, the immune system, and the muscular system.

Why Phytocannabinoids Matter

Machines, whether due to natural aging, poor maintenance, or damage, may malfunction. And like those machines, our body’s systems and parts can break down and malfunction, causing issues within the entire body and any number of health conditions.

Endocannabinoids help maintains your body’s health, but if the level of endocannabinoids in the body declines, in theory, they’d only be able to maintain the body’s current state of health. As such, there likely wouldn’t be enough to stop it from declining any further. Over time, the health level decreases gradually, and in the process, creates bigger health problems.

That’s where phytocannabinoids, such as CBD come into play.

How CBD Works in the Body

Research has taught us that when CBD bonds with either the CB1 or CB2 receptors in the body, it either alters or improves that receptor’s capabilities, which improves that receptor’s functionality.

If the body is suffering a cannabinoid deficiency, adding them to your body, for example, by using CBD gummies for stress, helps to equalize the deficiency. Right now, studies point to the theory that cannabinoids are a finite resource. The deficiency of cannabinoids may cause a number of health issues, including irritability and headaches.

Essentially, using CBD enables us to boost our ECS. Because it bonds with our CB1 and CBD2 receptors, CBD helps the body maintain vital health functions and helps restore balance, also known as homeostasis, within the body. This is the reason it has so many health benefits.

CBD Benefits

When you really think about it, the majority of health problems can be traced back to an imbalance somewhere in the body.

In a healthy body, all is as it should be, and the body is balanced. In an unhealthy body, however, there is either too much or too little of something (or multiple somethings). This creates a disruption in homeostasis and presents a variety of symptoms, which vary depending on the nature of the imbalance.

Think about the various health conditions that are a result of imbalance, and how CBD can help improve these conditions by restoring balance:

  • Inflammation: This is often characterized by a part of your body swelling, and sometimes becoming hot. It can be incredibly painful, and range from mild, to severe enough to incapacitate someone. Inflammation in the body is linked to autoimmune disorders, arthritis, and bacterial infections. CBD can be helpful to treat inflammation because it suppresses the inflammatory pathways and responses, stimulates regulatory cell production, and manages our pain perception.
  • Seizures: Seizures are the result of erratic electrical impulses in the brain, which causes violent shaking in the body. In patients suffering from two severe forms of epilepsy known as Lennox Gaustat Syndrome and Dravet Syndrome, CBD reduces the number of seizures because it slows down the excitatory nerve activity and subdues the brain’s reaction to the intense signals that cause the overload.
  • Anxiety and stress: Most people experience stress and anxiety as a response to situations that are perceived as unwanted, dangerous, or risky. Hormonal imbalance or excessive messages in the brain boosts cortisol levels and causes you to feel stress. CBD combats this by regulating how your brain responds to stress signals and maintaining normal cortisol levels.

These, of course, are only a few examples of the studies supporting CBD as an effective treatment.

There are hundreds of other studies supporting its use to treat a wide number of other conditions, such as addiction, acne, depression, schizophrenia and more. It’s all because of our ECS, and the fact that our bodies contain parts linked directly to the cannabis plant is pretty amazing.

SOURCE: https://www.latintimes.com/how-cbd-and-endocannabinoid-system-work-together-454648

Applied BioSciences $APPB: CBD vs THC – Full Spectrum, Broad Spectrum and Pure Isolate 2020 Comparison Guide $APH.ca $GBLX $PFE $ACG.ca $ACB.ca $WEED.ca $HIP.ca $WMD.ca $CGRW

Posted by AGORACOM-Eric at 2:34 PM on Tuesday, January 14th, 2020

SPONSOR: Applied BioSciences is a vertically integrated company focused on the development and commercialization of novel, science-driven, synthetic cannabinoid therapeutics / biopharmaceuticals; targeting the endocannabinoid system to treat a wide-range of diseases across multiple therapeutic areas. Click Here for More Info

A properly updated 2020 guide on CBD versus THC along with a complete review of the entourage effect differences and health benefits of using a full spectrum, broad spectrum or pure isolate CBD-infused product.

HealthMJ is actively mapping out the entire CBD ecosystem, from the best CBD oils, gummies, skincare, salves/balms, drinks/beverages and pet products – we got you covered; and one of the most popular questions we receive from our attentive audience is how CBD vs THC works; more specifically the differences between full spectrum CBD, broad spectrum CBD and pure isolates.

As the rapidly shifting landscape of medicinal cannabis continues to unfold in 2020, hemp and marijuana plants are both spectacles to watch in their own right given the prominent cannabinoid community of compounds, namely in THC and its cousin phytocannabinoid CBD.

With all of the new information coming out about CBD and its potential health benefits, it’s only fair that you might question how CBD compares to marijuana or THC-infused products and so forth. Many individuals continue to be concerned about CBD, and while there are many risks and dangerous concerns to address, research says maybe you should consider the options to get ahead of the curve and know the variations best available for you.

When it comes to terms like CBD, THC, full-spectrum, broad-spectrum, and isolates; it’s hard to know and fully understand what these terms mean and just what the differences are between them or how they compare to one another. But our CBD vs THC guide is designed to do just that; remove the clutter, simplify the terminology and showcase each advantage they all have independently as well as talk about the ‘entourage effect’.

The thing is, there is a lot of varying CBD and THC-infused product information available, and it is so very important to educate yourself before passing any judgment on these products. Making an effort to be in the know will not only increase your knowledge base but just might present you with life-changing information given your occupation, bodily needs or desired medicinal effects.

Understanding that “knowledge is power,” we put together a guide the will detail each of these items in turn (CBD, THC, full-spectrum, broad-spectrum, and isolates) as well as compare them and explain to you how each of these factors might relate to the other.

We will share with you various statistics, studies, definitions, and a ton of valuable information for each subject. To begin, we will break down each subject separately, and then we will come back and tie some information together for your reference.

We hope you will tune into this CBD and THC overview breakdown and the valuable information presented within our cannabis oil-infused product guide for buying the best full-spectrum, broad-spectrum or pure isolate option for you.

CBD: All the Rage, None of the High

CBD products have taken the world by storm. While it has quickly become the most popular best-selling herbal extract in the health and wellness industry last year, many are still on the fence whether or not to use a CBD-infused supplement. Have you tried them yet? Are you scared to take that step and open the door to the possibilities of what CBD can provide for you? CBD products were initially quite controversial as they are instantly associated with marijuana.

The truth is, CBD really is not comparable to marijuana and, in fact, many times contains no THC (which is the property that typically enacts psychoactive responses in use of marijuana) or a minuscule percentage.

Additionally, CBD products are heavily regulated as to how much THC can legally be in them for over-the-counter distribution. It is no secret by now CBD has become a go-to option for many men and women looking for a natural and potentially reliable solution for issues such as pain relief, anxiety, irritation, and the like. Before choosing a CBD product, it is important to understand the difference between the three of the most common-types of formulas, which are full-spectrum (with THC), broad-spectrum (no-THC) and isolate (pure CBD). Fortunately, this post is here to help.

Are you curious yet? Let’s dive a bit deeper.

What Exactly is CBD?

CBD is short for cannabidiol. This cannabidiol is otherwise known as a phytocannabinoid. These cannabinoids come directly from the cannabis plant. Cannabis plants contain more than 100 cannabinoids in them.

When minerals are extracted from the cannabis plant, CBD accounts for approximately 40% of the extracts, which results in CBD being readily available for processing. CBD can be obtained from hemp without THC in the extraction.

What does that mean? THC is the property that often gives cannabis a bad name. It is THC that produces the “high” that is associated with some cannabis usage, particularly smoking cannabis. However, you should know that THC is either extremely limited or completely non-existent in CBD when it is produced.

In fact, many manufacturers of CBD products extract the cannabidiol with an extreme process specifically for the purpose of delivering a pure product and reducing THC levels. In this manner, the CBD then does not make you high and formats to legal regulations as well.

The Benefits of CBD

Studies have shown that CBD products can produce a significant number of health benefits, many of which you may not have ever been aware of. Research has been increasing, but there is also still a lot to learn about CBD.

There are many benefits that have been discovered through studies and trials thus far. Here are a few of the most common and well-known benefits of CBD products:

  • Pain Relief
  • Anti-inflammatory properties
  • Anxiety relief
  • Cancer treatment and relief
  • Epilepsy and seizure disorder treatments
  • Alzheimer’s treatment
  • Migraine relief
  • Fight acne
  • Fights neurological symptoms and disorders

You might be able to pick out a few of the items on this list that have been primarily untreatable with everyday medication. When there is medication available, it can have extensive side effects.

But consider a safe and legal treatment to things like cancer, epilepsy, and Alzheimer’s – amongst other hard to treat diagnoses. Does this mean CBD will help your body heal from these disorders, or will it simply help relieve the symptoms?

Research and studies are still new and not fully conclusive. It is hard to say whether CBD could essentially eliminate any of the disorders listed, but if it can help fight or treat the associated symptoms, it is certainly worth consideration.

To give you an idea of how CBD works with these various disorders, let’s break a few of them down further.

CBD and Alzheimer’s Treatment

Alzheimer’s has long been a disorder that is primarily untreatable. Of course, there is medication to help those with Alzheimer’s, but it does little by way of reducing symptoms or slowing the process of the disease.

Alzheimer’s is primarily a brain disorder that progresses rather slowly at most times. It can move quickly though in some people. Alzheimer’s causes the victim to lost memories, history, and even the memory of how to complete specific skills necessary to care for themselves.

As Alzheimer’s progresses, many people revert to old memories and don’t know the people closest to them when they see them. They forgot how to do basic tasks and ultimately become unable to care for themselves safely.

All of these effects of Alzheimer’s are functionally related to the brain suffering from inflammation. This inflammation often causes excessive oxygen to build-up, which in turn leads to the effects we are familiar with as Alzheimer’s. The brain cells become blocked and therefore decline.

In comes CBD products, recent studies show that CBD can reduce this inflammation, allowing that oxygen that has built up due to brain cell blockage to seep out and therefore decreasing many Alzheimer’s symptoms.

This systematic process from CBD acts as an antioxidant for the brain cells by reducing or eliminating the inflammation that causes blockage and therefore causes the disease to take full form. With this relief, the effects of Alzheimer’s are greatly reduced and slowed.

This is not to say CBD cures Alzheimer’s but rather that it can reduce the process and provide relief of many of the symptoms, straight from the root cause.

CBD and Epilepsy Treatment

Epilepsy and other seizure disorders have been studied for health benefits related to CBD treatment. Epilepsy is another neurological disorder in which the sensory processes in your brain are triggered, which then leads to seizures.

Epilepsy has been challenging to treat through the years and at times, is left untreated. There are medications available, but there is no guarantee they will work. They may reduce seizures or the intensity of seizures, but the results vary on individuals, and, of course, the results are only as good as the medicine available.

CBD, also, may not be effective for every user. However, it has been found in studies to dramatically reduce the number of seizures as well as the length of seizures in those affected by the disease.

In 2018, the FDA approved Epidiolex to be used for epilepsy treatment in certain situations. There are two forms of epilepsy it has been approved to treat and an age requirement as well. Epidiolex is a formula of CBD that is purely plant-based but has been studied and researched for its effectiveness in regards to epilepsy treatment.

CBD Pain & Anti-Inflammatory Relief

For a number of years, chronic pain has been treated with pain relievers. Pain relievers that can cause dependency and addiction for the user and often produce side effects that far outweigh the relief of the pain.

Not only can pain relievers lead to addiction but essentially, they can become ineffective because of the dependence effect they tend to have on the user. This is an unfortunate effect for those who are simply seeking relief.

We’ve grouped Pain relief and anti-inflammatory properties together here because they are often related. Chronic pain is typically directly related to inflammation, as are various diseases and disorders that lead to common pain, fibromyalgia, sclerosis, lupus, etc.

Research is still quite limited on CBD’s abilities to reduce pain or inflammation, and therefore, there is no FDA seal of approval yet, but that doesn’t mean there isn’t information available for review.

It is believed through current studies that CBD directly communicates to your ECS or endocannabinoid system. This system signals cells to emit pain signals to your body when an area is damaged. CBD interacts with ECS to improve the quality of these signals, relieving the feelings of pain or inflammation within your body.

CBD and Anxiety Relief

Anxiety has become one of the fastest rising disorders. Anxiety continues to become a common diagnosis, but it shouldn’t be. In this frantic world that is constantly changing and evolving, anxiety is the last thing we should be worried about, and clearly, it is all about “worry.”

Again, research is just beginning, and the results are currently limited. The results of these studies continue to be tested, but for now, we work with what limited information we have available. Studies are showing that CBD can dramatically reduce anxiety and the effects of anxiety.

How does that work? CBD enhances calming properties through the brain. CBD somehow is able to bind to those brain receptors that trigger the anxiety response from your brain, and therefore, your anxiety is reduced, and you remain calmer and more reasonable rather than anxious and concerned.

Do You See a Connection?

Many of the disorders and symptoms you see above have something in common, they are triggered by cells or brain receptors that essentially lead to the disease or disorder. CBD appears to work quite well with disorders that essentially start with brain function.

Studies are still limited and are still taking place. Results are varied, and there is not yet enough evidence to truly rely on CBD, but there are positive results and signs thus far. While many of the disorders we specifically discussed are brain-related, CBD can have positive effects on other ailments as well.

The Legalities of CBD

CBD-infused product supplementation was the number one most trending ingredient in 2019. They have become more pronounced and popular in recent years as people discover just what CBD can offer for health benefits. There are a number of benefits and things still being discovered about CBD and what it has to offer.

It seems like everywhere you go, you can find CBD products from oils, gummies, sprays, and lotions to even CBD pet products. But is it really legal? How do you know it won’t cause you legal issues in the end?

Cannabis is certainly not new, but it still has limited legality for sales, use, and distribution. It cannot be openly sold in many states. Only a few states have passed bills allowing recreational or medicinal use of marijuana in a legal capacity.

However, in 2018, the Farm Bill was passed/updated, and restrictions on CBD specifically were removed from various legal restrictions if the CBD is extracted from a hemp plant. It is now legal to produce, buy, and sell CBD products IF they contain less than .3% THC.

The primary statement here is the products must fall into the guidelines of following the THC level guidelines. Many CBD companies simply meet the minimum guidelines while others take it even farther and purify their CBD or even produce a formula with 0% THC.

SOURCE: https://www.healthmj.com/cbd/thc-full-spectrum-broad-spectrum-isolate/